Voltage-Gated Calcium Channels

Voltage-Gated Calcium Channels

4.11 - 1251 ratings - Source

oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar macological targets in the treatment of a variety of disorders, such as epi lepsy, hypertension, and pain. Voltage-gated calcium channels have there fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac tivity, the book delves into a provocative overview of the history of the cal cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat ing, permeation, modulation and interactions with members of the exo- totic machinerya€”contributed by both established leaders and rising stars in the field.Gerald W. Zamponi ... Sequence alignment and ribbon diagrams for selective N- type voltage-sensitive calcium channel blockers from three different cone snail species, A) CVID from C. cams, B) GVIA from ... 5). As found for snake and the spider toxins, the lack of sequence homology among CO-conotoxins suggests that theanbsp;...

Title:Voltage-Gated Calcium Channels
Author:Gerald W. Zamponi
Publisher:Springer Science & Business Media - 2005-02-10


You Must CONTINUE and create a free account to access unlimited downloads & streaming