Using different viral models, molecular pathways regulated by viral genes and their role in the pathogenesis of infection are analyzed. The book also offers an update of known signaling pathways in apoptosis and their role in normal and infected cells. Special emphasis is given to molecular pathways underlying viral transformation and oncogenesis and how research in this area is opening opportunities in cancer therapy.... (E1a, E1b, E3 and E4) code for proteins involved, amongst other things, in overcoming premature death of the host cell. ... The major E1a proteins have been shown to bind the transcriptional co-activators of p53 [p300/CREB-binding proteinanbsp;...
|Title||:||Viruses and Apoptosis|
|Publisher||:||Springer Science & Business Media - 2013-04-18|