In the field of immunology, type 1 diabetes has become one of the major areas of investigation with studies that span from characterization of key molecules to trials for the prevention of the disease. Type 1 Diabetes : Molecular, Cellular and Clinical Immunology communicates both the background and the most recent understanding of this disorder, which will almost certainly be central to elucidating the etiology of autoimmunity, and in particular of organ specific autoimmunity. The book covers immunogenetics, immunopathogenesis, epidemiology, disease prediction and clinical application of current knowledge. Both scientists seeking to understand and prevent type 1 diabetes/autoimmunity as well as physicians caring for families with type 1 diabetes will be interested in this book.ESSAY. D. Was. There. Type. 1. Diabetes. in. the. Olduvai. Gorge? David. V. Serreze. and. Derry. C. Roopenian. The T cell ... The question then becomes why are genes contributing to T1D still maintained in the human gene pool? Perhaps ... These functional outcomes include positive selection, induction of effector activity, or apoptotic deletion either in the thymus (negative selection) or in the periphery.
|Title||:||Type 1 Diabetes|
|Author||:||George S. Eisenbarth|
|Publisher||:||Springer Science & Business Media - 2004-11-12|