The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.2009). The global reduction in numerous DNA repair pathways in hypoxic cells can therefore contribute to an ... For example, our laboratory and others have suggested that DNA repair-deficient hypoxic tumor cells can be targeted using the concept of contextual synthetic lethality (Chan and ... This is similar to the use of PARP inhibitors in ovarian cancers, which are defective in HR because of a loss ofanbsp;...
|Title||:||Tumor Microenvironment and Cellular Stress|
|Author||:||Constantinos Koumenis, Ester Hammond, Amato Giaccia|
|Publisher||:||Springer Science & Business Media - 2013-11-23|