As the first detailed overview of the subject, Tight Junctions brought together diverse perspectives from leading investigators to provide a multidisciplinary overview of the field. Since its publication in 1992, there has been an explosion of information about tight junctions, particularly in the area of molecular structure, cell and molecular biology, genetics and physiology. The field has advanced so fast and so far that it influences many areas of biology and now has practical implications for pharmacology of drug delivery and understanding a wide range of diseases altering epithelial permeability.Only the freeze-fracture replication of cellular membranes allows assessment of whether the fibrils that constitute the junction are continuous, and form an uninterrupted belt called a zonule around the cellular body (Diagram b, Figure 28.2a) oranbsp;...
|Author||:||Marcelino Cereijido, James M. Anderson|
|Publisher||:||CRC Press - 2001-06-26|