The Systems Biology of Parkinsonas Disease will be underpinned by new measurement techniques. This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound implications for the special vulnerability and role of this class of neurons.X W _ a#39;, 6 + a#39;, 9 _ v11 aSYNa#39;la#39; Misfolded aSYN 1 dsSYNX I v _ v T 7 8 PCr Phosphocreatine 4500 dlficr I _v10 l Cr Creatine 500 Cr I ... extracellular fluid (20 % of brain volume) bv9 is a user-defined flux that can be manipulated to reproduce exposition to toxins (see Fig. ... I k8 agt;alt; aSYN* X v10 I kgro agt;alt; PCr agt;alt; ADP _ krllo X Cr X ATP v11 I kf, 11agt;alt; AOx X ROS a 10.11 X AOX * regulated by the ATP/ADP ratioanbsp;...
|Title||:||Systems Biology of Parkinson's Disease|
|Author||:||Peter Wellstead, Mathieu Cloutier|
|Publisher||:||Springer Science & Business Media - 2012-05-08|