Retinal rod photoreceptor cells are specialized neurons in the vertebrate retina that initiate the visual response. Disease-linked mutations in the two rod outer segment (ROS) membrane proteins, rhodopsin and peripherin/rds, lead to various forms of retinal degeneration. Therefore, understanding the function of these proteins and how that function is supported by structure is key to unraveling the mechanism of both visual responses and retinal degenerative diseases.A B C Free-floating disk membranes \ Connecting cilium Cone call Figure 2. (A) Schematic diagram depicting the different regions of a rod cell. (B) Scanning electron micrograph of mouse ROSs attached to the retina. Scale bar: 1 [im (C)anbsp;...
|Title||:||Structural and Biophysical Studies on the Retinal Rod Outer Segment Membrane Proteins Peripherin/rds and Rhodopsin|
|Author||:||Thomas Craighead Edrington|
|Publisher||:||ProQuest - 2008|