Side Reactions in Organic Synthesis

Side Reactions in Organic Synthesis

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Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure-reactivity relationship of organic compounds. This textbook highlights the competing processes and limitations of the most important reactions used in organic synthesis. By allowing chemists to quickly recognize potential problems this book will help to improve their efficiency and success-rate. A must for every graduate student but also for every chemist in industry and academia. Contents: 1 Organic Synthesis: General Remarks 2 Stereoelectronic Effects and Reactivity 3 The Stability of Organic Compounds 4 Aliphatic Nucleophilic Substitutions: Problematic Electrophiles 5 The Alkylation of Carbanions 6 The Alkylation of Heteroatoms 7 The Acylation of Heteroatoms 8 Palladium-Catalyzed C-C Bond Formation 9 Cyclizations 10 Monofunctionalization of Symmetric Difunctional Substrates... Determination of the pKa of AcOEt: BrAcnsted correlation for deprotonation of a simple oxygen ester in aqueous solution. ... 38 King, J. F.; Rathore, R.; Guo, Z.; Li, M.; Payne, N. C. Experimental evidence for negative hyperconjugation as a ... 42 Delpuech, J.-J.; Nicole, D. J. Thermodynamic and kinetic acidities in DMSO.

Title:Side Reactions in Organic Synthesis
Author:Florencio Zaragoza Dörwald
Publisher:John Wiley & Sons - 2006-03-06


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