Scale-Up and Optimization in Preparative Chromatography

Scale-Up and Optimization in Preparative Chromatography

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Presenting guidelines to predict and improve separation system performance, this book contains numerous case studies illustrating the practice of scale-up principles in process development. It offers solutions to limitations that occur in real-world purification schemes; methods to model, optimize, and characterize nonlinear separation processes; data comparisons from all stages of production; and industrial separation schemes for products such as synthetic molecules, antibody fragments, IgG, growth factors, and plasmid DNA. The book covers external constraints, separation economics, correlations for transport and kinetic phenomena, and the configuration and parameters of column design.Principles and Biopharmaceutical Applications Anurag Rathore, Ajoy Velayudhan ... Rather, one must depend heavily upon heuristic considerations, and perhaps the simplest is to recognize that concentration and thermodynamic activity are independent of each ... Representative separation trajectories. solution, now at a concentration that competes with the protein Mass Transfer and Fluid Mechanics 35.

Title:Scale-Up and Optimization in Preparative Chromatography
Author:Anurag Rathore, Ajoy Velayudhan
Publisher:CRC Press - 2002-09-26


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