These results support the notion that breast cancer secreted NDPK stimulates angiogenesis via P2YR/VEGFR2 cooperative signaling and suggests that this signaling cascade may be important in describing endothelial homeostasis in both tumor as well as normal vasculature. The findings detailed in this dissertation describe a novel pathway with properties that present a potential therapeutic target in the fight against breast cancer.This information allowed us to determine NDPK activity when we were varying levels of ADP donor or GTP acceptor. An apparent Km ... 5C vs 5D (4500 nmol ATP/ I¼g protein min-1 is 2X that of 2250 nmol ATP/ I¼g protein min-1). All subsequentanbsp;...
|Title||:||Purinergic Regulation of Angiogenesis: Pathological Implications|
|Author||:||Sharif Mohamed Rumjahn|
|Publisher||:||ProQuest - 2008|