Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins. Topics include: Computational methodologies High-throughput screening methods Pharmaceutical cocrystals Thermally-induced and solution-mediated phase transformations Amorphous solids Crystallography preparation and characterization The amorphous stateFor the purposes of this chapter, physical form will be taken to mean any solid form of the compound being examined, whether ... Automated crystallization approaches allow the basic process steps involved in a typical manual solution ... amounts of compound available during the earliest stages of drug development for the initial assessment of polymorphism (4, 6). ... number of trials carried out in parallel and the increased speed at which individual experiments were implemented (9).
|Title||:||Polymorphism in Pharmaceutical Solids, Second Edition|
|Author||:||Harry G. Brittain|
|Publisher||:||CRC Press - 2009-07-27|