Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of qqmolecular pathogenesisqq of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways. The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine. This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows. * Exam MasterAr web site will host qSelf-assessmentq questions that students can use to study for the molecular section of the board exam * Companion Web Site a will host a complete set of PowerPoint slides: to include images from the book and additional images for teaching; course materials; lecture materials * Teaches from the perspective of aintegrative systems biology, which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease * Outlines the principles and practice of molecular pathology * Explains the practice of amolecular medicine and the translational aspects of molecular pathologyRelatively few gene tests were clinically available in the late 1990s, whereas over 1, 000 are available today. Further ... The second section focuses on molecular pathology, DNA replication, and DNA repair mechanisms. ... The DNA is associated with a large number of proteins (histones and others) that serve regulatory functions and package the genetic material into these large chromosomal units.
|Author||:||William B. Coleman, Gregory J. Tsongalis|
|Publisher||:||Academic Press - 2009-03-10|