Molecular and Functional Models in Neuropsychiatry

Molecular and Functional Models in Neuropsychiatry

4.11 - 1251 ratings - Source

The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.... Cha JH (2007) Histones associated with downregulated genes are hypo- acetylated in Huntingtona#39;s disease models. Hum Mol ... in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry.

Title:Molecular and Functional Models in Neuropsychiatry
Author:Jim J. Hagan
Publisher:Springer Science & Business Media - 2011-04-02


You Must CONTINUE and create a free account to access unlimited downloads & streaming