Models for Assessing Drug Absorption and Metabolism

Models for Assessing Drug Absorption and Metabolism

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Shows scientists in the pharmaceutical and biotechnology industries how to set up in situ and in vitro model systems. After an overview of general principles for characterizing and using the systems, chapters two through six describe methodologies for studying drug absorption and metabolism after ordiameter) crystallization dish are needed for the preparation and subsequent removal of the liver. ... above;4 lengths of autoclavable PVC tubing (3 mm i.d., 6 mm o.d.a€”320-cm pieces and 145-cm piece; and 3 three-way nylon stopcocks. ... The air is then displaced from all lines and the bubble trap by slowly pumping perfusion buffer through tubing. ... in a water bath at 40AdC as in method A. A 1-ml serological pipet attached to regulated carbogen or oxygen is placed into the P1 buffer, anbsp;...

Title:Models for Assessing Drug Absorption and Metabolism
Author:Ronald T. Borchardt, Philip L. Smith, Glynn Wilson
Publisher:Springer Science & Business Media - 1996-08-31


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