Protein pharmaceuticals form a fast-growing category in the arsenal of drugs. This book explores the nature of different analytical techniques and the way in which they are related to pharmaceutical proteins. In addition to serving the analytical chemist, this book is needed by the formulation scientist who is responsible for design and formulation of a pharmaceutical protein that can be monitored during production and over time.In variable selection, sets of CD spectra of the reference proteins are removed from the reference set until certain criteria are satisfied. ... 1.05); (b) all fractions are larger thana0.03 (ideally positive), (c) the fit of the reconstituted CD is within the noise level of the ... chainlength and environmental dependence of helices and sheets), alocally linearized model using a set of reference proteins is introduced.
|Title||:||Methods for Structural Analysis of Protein Pharmaceuticals|
|Author||:||Wim Jiskoot, Daan Crommelin|
|Publisher||:||Springer Science & Business Media - 2005-12-05|