Marmoset 17[alpha]-hydoxylase/17,20-lyase Cytochrome P450

Marmoset 17[alpha]-hydoxylase/17,20-lyase Cytochrome P450

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The human adrenal cortex produces steroids crucial for salt and water balance in the kidney, blood and sugar homeostasis, immunosuppression, and peripheral sex steroid biosynthesis. The marmoset monkey (Callithrix jacchus), a small New World primate, is often utilized as a human model for biomedical research. This dissertation focuses on characterizing the marmoset adrenal gland to validate its use as a model for human in studies of the hypothalamus-pituitary-gonad and hypothalamus-pituitary-adrenal axes by first fully characterizing the marmoset adrenal cortex, and second identifying molecular explanations for differences observed between human and marmoset adrenal cortices.Slides were labeled by pencil or HistoPrep pen with the date and primary antibody concentrations then loaded onto a vertical slide carrier and hydrated by immersion in CitriSolv clearing agent baths (fresh, 3x10 dips + 5min), 100% ethanolanbsp;...

Title:Marmoset 17[alpha]-hydoxylase/17,20-lyase Cytochrome P450
Author:Jacquelene Christina Pattison
Publisher:ProQuest - 2008


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