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This book is an edited collection of the literature on leptin beginning with the discovery of leptin and a study of its affect on animals and in humans. Chapters will focus on the discovery, history, roles and regulation of leptin in all the major areas of physiology, as well as on assay methods, phylogeny and genetics. The timing of this volume is long overdue and is the first comprehensive coverage of leptin physiology in the field.The challenge lies in understanding the mechanisms of leptin responsiveness. ... While leptin trials in human obesity did not produce the expected weight loss in leptin replete obese humans, these ... Dr. Oral has been supported by the NM- funded Michigan Diabetes and Research Center as well as Michigan Peptideanbsp;...

Author:V. Daniel Castracane, Michael C. Henson
Publisher:Springer Science & Business Media - 2006-12-22


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