What are the main challenges of computational molecular biology once the genome projects are completed? Integrative Approaches to Molecular Biology focuses on molecular biology beyond sequences: from gene regulation to differentiation, a higher-level integration that will be a major theme in biology following conclusion of the genome program. It charts the course of the emerging discipline of integrative molecular biology from macromolecular sequences to a biological (and theoretical) perspective, showing that novel integrative methodologies and paradigms are emerging at the confluence of such disciplines as computer science, logic, linguistics, and mathematics. Following an introductory chapter by Richard Lewontin that offers a critique of the evolutionary process as one of engineering design, the first part of the book, on computational biology, addresses issues concerning protein and DNA sequences within genome projects and a federated infrastructure for databases. The second part brings together experimental, evolutionary, computational, and theoretical approaches dealing with regulation of gene expression, metabolic pathways, and cell differentiation. The book concludes with a chapter on problems and perspectives on artificial intelligence.Conceptual integration in molecular biology will depend on access to properly managed and well-integrated data resources, with databases ... Expert in separating signal from noise, many biologists suspect that computer scientistsa#39; concern with data modeling and data ... data models and formats are not equivalent to simple untidiness, they are equivalent to the sloppy preparation of laboratory material.
|Title||:||Integrative Approaches to Molecular Biology|
|Publisher||:||MIT Press - 1996|