Highly skilled experimenters present key techniques for the multidisciplinary study of inflammation in such conditions as inflammatory bowel disease, rheumatoid arthritis, renal disease, and cardiovascular disease. Described in step-by-step detail to ensure experimental success, the techniques are focused on the research and development of potential new antiinflammatory drugs in active target areas. The protocols are suitable for many current areas of drug discovery research, including transcription factors, cytokines, adhesion molecules, cyclooxygenase-2 (COX-2) inhibitors, free radicals, nitric oxide synthases, angiogenesis, wound healing, complement activation, immune rejection, and metalloproteinases..... inhibiting a specific mediator of inflammation, one must pose the question, a What is the physiological role of the new therapeutic target? ... For example, at the outset of inflammation there are many polymorphonuclear leukocytes that subsequently undergo apoptosis and are ... To address a specific point raised in your essay, you appear distressed that the facile test, carrageenan paw edema, respondsanbsp;...
|Author||:||Paul G. Winyard, D. A. Willoughby|
|Publisher||:||Springer Science & Business Media - 2003-01-01|