Immunoreceptor Tyrosine-based Inhibition Motifs

Immunoreceptor Tyrosine-based Inhibition Motifs

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Novel molecular motifs named Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation. Research on ITIM-bearing molecules has developed exponentially during the last three years, generating new concepts with important consequences in basic research and with exciting potential clinical applications. The present volume contains 15 reviews written by authors who all made significant contributions to the identification of ITIM-bearing molecules and the study of their biological properties. It constitutes the first synthesis ever published that is specifically devoted to this emerging topic.J Immunol 160:4662a€“4665 Alley TL, Cooper MD, Chen M, Kubagawa (1998) Genomic structure of PIR-B, the inhibitory member of ... Science 274:1906a€“1909 Binstadt BA, Brumbaugh KM, Dick CJ, Scharenberg AM, Williams BL, Colonna M, Lanier LL, Kinet JP, ... Proc Natl Acad Sci USA 95:2446a€“245.1 Bolen JB, Brugge JS (1997) Leukocyte protein tyrosine kinases: potential targets for drug discovery.

Title:Immunoreceptor Tyrosine-based Inhibition Motifs
Author:Marc Daeron, Eric Vivier
Publisher:Springer Science & Business Media - 2012-12-06


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