Biomedical research involving animals remains essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Following in the footsteps of its predecessors, the Handbook of Laboratory Animal Science, Volume II, Third Edition: Animal Models explains in great detail the comparative considerations underlying the choice of animal species and strains in different research disciplines. Efficient and humane experimental work with animals, in which subjects experience no avoidable pain and mental distress, requires skillful and conscientious staff. To this end, scientists apply the three Ras: replacing experiments on live animals with alternative methods, reducing the number of animals necessary to obtain valid results within experiments, and refining techniques to minimize the discomfort experienced by the animal participants.with increasing knowledge and experience, investigators in animal research will be able to identify still more specific, early ... The Organisation for Economic Co- operation and Development (OECD) has published aGuidance Document (GD) on ... of animals in regulatory toxicity tests and other experimental studies (OECD Series on Testing and Assessment, No. ... yearsa#39; worth of accumulated knowledge available for certain traditionally used animal species will guide the selection ofanbsp;...
|Title||:||Handbook of Laboratory Animal Science, Volume II, Third Edition|
|Author||:||Jann Hau, Steven J. Schapiro|
|Publisher||:||CRC Press - 2011-04-22|