Granulocytes and monocytes are key mediators of innate immunity and the inflammatory response. Expression of CD18; the beta chain of the leukocyte integrins, is transcriptionally regulated by retinoic acid (RA) in myeloid cells. This regulation requires stable integration into chromatin. Furthermore, full RA-responsiveness of the CD18 gene requires its proximal promoter, which lacks a retinoic acid response element (RARE) and is not directly bound by retinoic acid receptors (RARs). Rather, RA-responsiveness of the CD18 proximal promoter requires ets sites that are bound by GA-binding protein (GABP); the transcriptional co-activator p300 further increases CD18 RA-responsiveness.Granulocytes and monocytes are key mediators of innate immunity and the inflammatory response.
|Title||:||GABP and P300 are Essential Components of a Retinoic Acid-induced Enhanceosome in Myeloid Cells|
|Author||:||Karen K. Resendes|
|Publisher||:||ProQuest - 2006|