Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease. It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and students seeking current translational knowledge in epigenesis and epigenomics. Coverage includes the latest findings on epigenome-wide research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. Presents critical reviews that provide the means for reviewing and analyzing the epigenome as a whole, also discussing its translational potential Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and data analysis Includes coverage of relatively new topics, including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging              Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, ... Nature 2013;498(7455):511A15. ... Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K, et al. ... Cancer cell 2014; 26(5):707A21. ... Stenmark H. Rab GTPases as coordinators of vesicle traffic.
|Title||:||Epigenomics in Health and Disease|
|Author||:||Mario Fraga, Agustin Fernandez Fernandez|
|Publisher||:||Academic Press - 2015-10-12|