The United States Environmental Protection Agency (U.S. EPA) Office of Water (OW) initiated the Health Advisory Program in 1978 to provide information and guidance to individuals or agencies concerned with potential risk from drinking water contaminants for which no national regulations currently exist. Since that time, over 100 Health Advisories (HAs) have been published in final form for inorganic, organic, and microbial contaminants. This volume contains HAs for munitions chemicals developed as part of a Memorandum of Understanding between the U.S. EPA and the Department of the Army. To develop each HA, the authors reviewed toxicological data for each chemical and presented the relevant studies to allow an evaluation of the data without continued reference to the primary documents. Each HA has undergone critical internal review by the OW Toxicology Review Panel, EPA program offices, the EPA Reference Dose (RfD) Committee, the EPA Carcinogen Risk Assessment and Verification Enterprise (CRAVE) Committee, and the Army Medical Department (for munitions chemicals only). Finally, the HAs were reviewed by an external panel of experts in toxicology and risk assessments. Drinking Water Health Advisory: Munitions will be an important reference document for all DOD/DOE hazardous waste sites, drinking water professionals, and academic libraries.No dermal sensitization was indicated in male Hartley guinea pigs at 24 and 48 hr after a single challenge dose of HCE. ... Weeks and Thomasino (1976) calculated a dermal LD50 of agt;32 g/kg for male New Zealand White rabbits (four per group) ... Signs of toxidty included weight loss, but no skin irritation was evident.
|Title||:||Drinking Water Health Advisory|
|Author||:||Welford C. Roberts, William R. Hartley|
|Publisher||:||CRC Press - 1992-06-16|