DNA is the central repository of genetic information in the cell, yet it is under constant attack by chemical mutagens, radiation and other processes. Cells therefore put a great deal of resources into repairing any damage to this precious store. Mechanisms of DNA repair vary greatly in their level of complexity, from specific reversal mechanisms that involve a single protein, to sequential pathways that require many enzymes. But at the heart of all these mechanisms lie proteins that recognize damage to DNA, raising important questions about how damaged DNA may be distinguished. These recognition processes are now finally yielding their secrets to structural analysis. This volume focuses on DNA repair, with an emphasis on structural data where available.1996; Kubota et al. 1996), linking this protein to the BER pathway. A role for XRCC1 in BER is implicated by the correction of the defective phenotypes of Chinese hamster ovary cell lines EM9 and EMC11 by human XRCC1 cDNA ( Thompsonanbsp;...
|Author||:||Fritz Eckstein Eckstein, David M.J. Lilley|
|Publisher||:||Springer Science & Business Media - 2012-12-06|