DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.NHEJ is the primary repair pathway for DNA DSBs caused by ionizing radiation and cells deficient in NHEJ are exquisitely ... 2009). This may explain the discrepancy between the clinical and cellular radiosensitivity of FA patients and further studies ... Synthetic lethality is the concept that mutation in two genes leads to death, whereas mutation of either gene alone is ... The use of PARP inhibitors to target hypoxic tumor cells is an example of acontextual synthetic lethalitya, where aanbsp;...
|Title||:||DNA Repair and Cancer|
|Author||:||Srinivasan Madhusudan, David M. Wilson III|
|Publisher||:||CRC Press - 2013-01-22|