Model systems. Structurally defined bacterial enzymes. Structures and mechanisms of membrane-bound P450 enzymes. Regulatory mechanisms and physiological roles of cytochrome P450. Cytochrome P450 nomenclature and alignment of selected sequences. Rat and human liver cytochromes P450: substrate and inhibitor specificities and functional markers.Chapters emphasize structure, mechanism, biochemistry, and regulation. This edition offers expanded coverage of P450 crystal structures, site-specific mutagenesis as a probe of structure and function.
|Author||:||Paul R. Ortiz de Montellano|
|Publisher||:||Springer Science & Business Media - 1995-10-31|