Combinatorial Chemistry

Combinatorial Chemistry

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Explores a new approach to drug discovery, covers a selection of organic chemistry technologies now available, and explains how the new techniques allows chemical compounds to be synthesized much more quickly(a) (b) 120. 120100- 100- | 80 - 80 - Ar 60: Ar 60: 40- 4020. 20 0- 0= g : Ap X B1 B2 B3 B4 B5 B6 (U o o O + C C Cl CD Qu ... Figure 5.9 Ar: Percent of trypsin activity in the presence of added libraries relative to a blank (X) containing no added library material. ... Chart B.A.: percent of trypsin activity with the six sublibraries B1-B6 constructed from core molecule 2 and 15 of the 19 amino acid building blocks.

Title:Combinatorial Chemistry
Author:Stephen R. Wilson, Anthony W. Czarnik
Publisher:John Wiley & Sons - 1997-03-28


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