As cells mature they naturally stop dividing and enter a period called senescence. But cellular senescence can also be induced prematurely by certain oncogenes involved in cancer development. Cellular senescence, a growth-arrest program that limits the lifespan of mammalian cells and prevents unlimited cell proliferation, is attracting considerable interest because of its links to tumor suppression.The PTM instruction set that governs the expression of genes has been popularized as the Histone Code Hypothesis ... G1/S-phase transition H2A Acetylation K5 a Tip60 p300/CBP Activation Activation Phosphorylation S1 S139 ( H2A.X) a a ?
|Title||:||Cellular Senescence and Tumor Suppression|
|Author||:||Peter D. Adams, John M. Sedivy|
|Publisher||:||Springer Science & Business Media - 2010-01-23|