A Handbook for DNA-Encoded Chemistry

A Handbook for DNA-Encoded Chemistry

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This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry a€“ synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available a€œchemical spacea€ for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods... temperature 30.4 Analyze by LC/MS Step Pool 31 Pool all 96 wells into a single vessel Step Ethanol crash 32 Add Volume Total volume 32.1 5 M NaCl(aq) 270 I¼L 2.97 mL 32.2 Cold EtOH 5.93 mL 8.90 mL 32.3 aˆ’78AdC for a‰y30 min or aˆ’20 AdCanbsp;...

Title:A Handbook for DNA-Encoded Chemistry
Author:Robert A. Goodnow, Jr.
Publisher:John Wiley & Sons - 2014-04-10


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